STX1A/STX1B2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of STX1A/STX1B2.
Immunogen
A synthetic peptide corresponding to N-terminus of human STX1A, STX1B2.
Sequence
KDRTQELRTAKD-C
Host
Goat
Theoretical MW (kDa)
33.0, 33.2
Reactivity
Mouse
Specificity
This product is expected to recognize the products of 2 different genes. STX1A (NP_004594.1and NP_001159375.1) and STX1B (NP_443106.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.01-0.03 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The STX1A/STX1B2 polyclonal antibody (Cat # PAB6845) (0.003 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — STX1A
Entrez GeneID
6804Protein Accession#
NP_004594.1 (Gene ID : 6804);NP_001159375.1 (Gene ID : 112755);NP_443106.1 (Gene ID : 112755)Gene Name
STX1A
Gene Alias
HPC-1, STX1, p35-1
Gene Description
syntaxin 1A (brain)
Omim ID
186590Gene Ontology
HyperlinkGene Summary
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM
Other Designations
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Gene Info — STX1B
Entrez GeneID
112755Protein Accession#
NP_004594.1 (Gene ID : 6804);NP_001159375.1 (Gene ID : 112755);NP_443106.1 (Gene ID : 112755)Gene Name
STX1B
Gene Alias
STX1B1, STX1B2
Gene Description
syntaxin 1B
Omim ID
601485Gene Ontology
HyperlinkOther Designations
syntaxin 1B1|syntaxin 1B2
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Interactome
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Pathway
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Disease
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Publication Reference
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Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.
Kang Y, Leung YM, Manning-Fox JE, Xia F, Xie H, Sheu L, Tsushima RG, Light PE, Gaisano HY.
The Journal of Biological Chemistry 2004 Nov; 279(45):47125.
Application:IF, WB, Human, Rat, HEK 293 cells, Rat brain, Rat myocytes.
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Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.
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