GHRL polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GHRL.
Immunogen
A synthetic peptide corresponding to C-terminus of human GHRL.
Sequence
C-QDILWEEAKEAPADK
Host
Goat
Theoretical MW (kDa)
12.9
Reactivity
Human, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GHRL polyclonal antibody (Cat # PAB6842) (2 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — GHRL
Entrez GeneID
51738Protein Accession#
NP_057446.1;NP_001128413.1;NP_001128416.1;NP_001128417.1;NP_001128418.1Gene Name
GHRL
Gene Alias
MTLRP, obestatin
Gene Description
ghrelin/obestatin prepropeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq
Other Designations
ghrelin, growth hormone secretagogue receptor ligand|ghrelin/obestatin|ghrelin/obestatin preprohormone|motilin-related peptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor.
Ghigo E, Broglio F, Arvat E, Maccario M, Papotti M, Muccioli G.
Clinical Endocrinology 2005 Jan; 62(1):1.
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Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor.
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