CCKAR polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CCKAR.
Immunogen
A synthetic peptide corresponding to internal region of human CCKAR.
Sequence
C-FEASQKKSAKERKPST
Host
Goat
Theoretical MW (kDa)
47.8
Reactivity
Human, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:4000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CCKAR polyclonal antibody (Cat # PAB6798) (10 ug/mL) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.Immunocytochemistry
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCKAR
Entrez GeneID
886Protein Accession#
NP_000721.1Gene Name
CCKAR
Gene Alias
CCK-A, CCK1-R, CCKRA
Gene Description
cholecystokinin A receptor
Omim ID
118444Gene Ontology
HyperlinkGene Summary
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq
Other Designations
cholecystokinin type-A receptor|cholecystokinin-1 receptor
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Pathway
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Disease
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Publication Reference
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Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans.
Beglinger C, Degen L, Matzinger D, D'Amato M, Drewe J.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2001 Apr; 280(4):R1149.
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Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans.
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