CTSF polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CTSF.
Immunogen
A synthetic peptide corresponding to human CTSF.
Sequence
CGVNTMASSAVVD
Host
Goat
Theoretical MW (kDa)
53.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CTSF polyclonal antibody (Cat # PAB6781) (0.3 ug/mL) staining of human ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CTSF
Entrez GeneID
8722Protein Accession#
NP_003784.2Gene Name
CTSF
Gene Alias
CATSF
Gene Description
cathepsin F
Omim ID
603539Gene Ontology
HyperlinkGene Summary
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of specific cellular genes up-regulated late in adenovirus type 12 infection.
Dorn A, Zhao H, Granberg F, Hosel M, Webb D, Svensson C, Pettersson U, Doerfler W.
Journal of virology 2005 Feb; 79(4):2404.
Application:WB-Tr, Human, HeLa cells.
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Identification of specific cellular genes up-regulated late in adenovirus type 12 infection.
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