CHMP5 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CHMP5.
Immunogen
A synthetic peptide corresponding to human CHMP5.
Sequence
C-NKDGVLVDEFGLPQ
Host
Goat
Theoretical MW (kDa)
24.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
CHMP5 polyclonal antibody (Cat # PAB6771) (0.5 ug/mL) staining of K-562 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CHMP5
Entrez GeneID
51510Protein Accession#
NP_057494.2Gene Name
CHMP5
Gene Alias
C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2
Gene Description
chromatin modifying protein 5
Omim ID
610900Gene Ontology
HyperlinkGene Summary
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM
Other Designations
OTTHUMP00000021197|SNF7 domain containing 2
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Interactome
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Pathway
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Publication Reference
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The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.
Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J.
The Journal of Biological Chemistry 2005 Mar; 280(11):10548.
Application:WB-Re, WB-Tr, Monkey, COS-7 cells, Recombinant protein.
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The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.
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