SERPINI1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SERPINI1.
Immunogen
A synthetic peptide corresponding to human SERPINI1.
Sequence
C-TMNTSGHDFEEL
Host
Goat
Theoretical MW (kDa)
46.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SERPINI1 polyclonal antibody (Cat # PAB6763) (1 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SERPINI1
Entrez GeneID
5274Protein Accession#
NP_005016.1Gene Name
SERPINI1
Gene Alias
DKFZp781N13156, PI12, neuroserpin
Gene Description
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
neuroserpin|serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1
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Interactome
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Disease
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Publication Reference
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Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies.
Onda M, Belorgey D, Sharp LK, Lomas DA.
The Journal of Biological Chemistry 2005 Apr; 280(14):13735.
Application:WB-Ce, Monkey, COS-7 cells.
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Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies.
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