PCSK9 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PCSK9.
Immunogen
A synthetic peptide corresponding to C-terminus of human PCSK9.
Sequence
CRSRHLAQASQELQ
Host
Goat
Theoretical MW (kDa)
74.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
PCSK9 polyclonal antibody (Cat # PAB6761) staining (0.2 ug/mL) of McA cell lysates: untransfected (Lane 1), transfected with wild type human PCSK9 (Lane 2), transfected with S127R human PCSK9 (Lane 3).
Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PCSK9 polyclonal antibody (Cat # PAB6761) (4 ug/mL) staining of paraffin embedded human kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PCSK9
Entrez GeneID
255738Protein Accession#
NP_777596.2Gene Name
PCSK9
Gene Alias
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1
Gene Description
proprotein convertase subtilisin/kexin type 9
Gene Ontology
HyperlinkGene Summary
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq
Other Designations
OTTHUMP00000009833|convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1
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Interactome
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Disease
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Publication Reference
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Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia.
Sun XM, Eden ER, Tosi I, Neuwirth CK, Wile D, Naoumova RP, Soutar AK.
Human Molecular Genetics 2005 Mar; 14(9):1161.
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Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia.
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