PCSK9 polyclonal antibody (Cat # PAB6761) staining (0.2 ug/mL) of McA cell lysates: untransfected (Lane 1), transfected with wild type human PCSK9 (Lane 2), transfected with S127R human PCSK9 (Lane 3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London.
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq
OTTHUMP00000009833,convertase subtilisin/kexin type 9 preproprotein,neural apoptosis regulated convertase 1