CCL3L1/CCL3 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CCL3L1/CCL3.
Immunogen
A synthetic peptide corresponding to human CCL3L1, CCL3.
Sequence
C-EWVQKYVSDLELSA
Host
Goat
Theoretical MW (kDa)
10.1, 10.2
Specificity
This product is expected to recognize the products of 2 different genes which are almost identical.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCL3
Entrez GeneID
6348Protein Accession#
NP_002974.1 (Gene ID : 6348);NP_066286.1 (Gene ID : 6349)Gene Name
CCL3
Gene Alias
G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3
Gene Description
chemokine (C-C motif) ligand 3
Gene Ontology
HyperlinkGene Summary
Macrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988 [PubMed 3279154]). Sherry et al. (1988) [PubMed 3058856] demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM
Other Designations
LD78 alpha beta|small inducible cytokine A3 (homologous to mouse Mip-1a)
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Gene Info — CCL3L1
Entrez GeneID
6349Protein Accession#
NP_002974.1 (Gene ID : 6348);NP_066286.1 (Gene ID : 6349)Gene Name
CCL3L1
Gene Alias
464.2, D17S1718, G0S19-2, LD78, LD78BETA, MGC104178, MGC12815, MGC182017, MIP1AP, SCYA3L, SCYA3L1
Gene Description
chemokine (C-C motif) ligand 3-like 1
Gene Ontology
HyperlinkGene Summary
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene and a partial pseudogene. This record represents the more telomeric full-length gene. [provided by RefSeq
Other Designations
small inducible cytokine A3-like 1
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Interactome
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Pathway
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Disease
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Publication Reference
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The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G, Nibbs RJ, Freedman BI, Quinones MP, Bamshad MJ, Murthy KK, Rovin BH, Bradley W, Clark RA, Anderson SA, O'connell RJ, Agan BK, Ahuja SS, Bologna R, Sen L, Dolan MJ, Ahuja SK.
Science 2005 Mar; 307(5714):1434.
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The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
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