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Last updated: 2016/12/4
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PDE5A polyclonal antibody

  • Catalog # : PAB6741
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of PDE5A.
  • Immunogen:
  • A synthetic peptide corresponding to human PDE5A.
  • Sequence:
  • C-LINGESGQAKRN
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 100, 94.8, 93.6
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize all 4 reported isoforms (as represented by NP_001074, NP_236914, NP_246273). NP_237223 has been retracted (280905)
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:16000)
    Western Blot (0.3-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • PDE5A polyclonal antibody (Cat # PAB6741) staining (0.3 ug/mL) of human lung lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • HEK293 overexpressing PDE5A and probed with PDE5A polyclonal antibody (Cat # PAB6741) (mock transfection in first lane), tested by Origene.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8654
  • Protein Accession#:
  • NP_001074;NP_237223;NP_246273;NP_236914
  • Gene Name:
  • PDE5A
  • Gene Alias:
  • CGB-PDE,CN5A,PDE5,PDE5A1
  • Gene Description:
  • phosphodiesterase 5A, cGMP-specific
  • Gene Summary:
  • This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq
  • Other Designations:
  • cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase,phosphodiesterase 5A
  • Gene Pathway
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