ADH1A/ADH1B/ADH1C polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ADH1A/ADH1B/ADH1C.
Immunogen
A synthetic peptide corresponding to human ADH1A/ADH1B/ADH1C.
Sequence
STAGKVMKCKA
Host
Goat
Theoretical MW (kDa)
39.9
Reactivity
Human
Specificity
This antibody is expected to recognize the alpha (ADH1A, NP_ 000658), the beta (ADH1B, NP_000659) and gamma (ADH1C, NP_000660) polyvariants of human alcohol dehydrogenase.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The ADH1A/ADH1B/ADH1C polyclonal antibody (Cat # PAB6725) (0.3 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADH1A
Entrez GeneID
124Protein Accession#
NP_000658.1 (Gene ID : 124);NP_000659.2 (Gene ID : 125);NP_000660.1 (Gene ID : 126)Gene Name
ADH1A
Gene Alias
ADH1
Gene Description
alcohol dehydrogenase 1A (class I), alpha polypeptide
Omim ID
103700Gene Ontology
HyperlinkGene Summary
This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers. [provided by RefSeq
Other Designations
ADH, alpha subunit|alcohol dehydrogenase 1 (class I), alpha polypeptide|aldehyde reductase|class I alcohol dehydrogenase, alpha subunit
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Gene Info — ADH1B
Entrez GeneID
125Protein Accession#
NP_000658.1 (Gene ID : 124);NP_000659.2 (Gene ID : 125);NP_000660.1 (Gene ID : 126)Gene Name
ADH1B
Gene Alias
ADH2, DKFZp686C06125
Gene Description
alcohol dehydrogenase 1B (class I), beta polypeptide
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq
Other Designations
ADH, beta subunit|alcohol dehydrogenase 2 (class I), beta polypeptide|alcohol dehydrogenase IB (class I), beta polypeptide|aldehyde reductase|class I alcohol dehydrogenase, beta subunit
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Gene Info — ADH1C
Entrez GeneID
126Protein Accession#
NP_000658.1 (Gene ID : 124);NP_000659.2 (Gene ID : 125);NP_000660.1 (Gene ID : 126)Gene Name
ADH1C
Gene Alias
ADH3
Gene Description
alcohol dehydrogenase 1C (class I), gamma polypeptide
Omim ID
103730Gene Ontology
HyperlinkGene Summary
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq
Other Designations
ADH, gamma subunit|alcohol dehydrogenase 3 (class I), gamma polypeptide|aldehyde reductase|class I alcohol dehydrogenase, gamma subunit
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Interactome
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Pathway
- 1- and 2-Methylnaphthalene degradation
- 1- and 2-Methylnaphthalene degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- 3-Chloroacrylic acid degradation
- 3-Chloroacrylic acid degradation
- Drug metabolism - cytochrome P450
- Drug metabolism - cytochrome P450
- Drug metabolism - cytochrome P450
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Disease
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Publication Reference
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Molecular cloning of a full-length cDNA for human alcohol dehydrogenase.
Ikuta T, Fujiyoshi T, Kurachi K, Yoshida A.
PNAS 1985 May; 82(9):2703.
Application:Screening, WB-Re, Bacteria, Bacteria, Recombinant proteins.
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Molecular cloning of a full-length cDNA for human alcohol dehydrogenase.
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