HSD17B10 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
HSD17B10 polyclonal antibody (Cat # PAB6724) staining (0.3 ug/mL) of human brain lysate (RIPA buffer, 30 ug total protein per lane).
Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HSD17B10.
Immunogen
A synthetic peptide corresponding to human HSD17B10.
Sequence
CIRLDGAIRMQP
Host
Goat
Theoretical MW (kDa)
26.9, 26
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HSD17B10 polyclonal antibody (Cat # PAB6724) staining (0.3 ug/mL) of human brain lysate (RIPA buffer, 30 ug total protein per lane).
Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSD17B10
Entrez GeneID
3028Protein Accession#
NP_004484Gene Name
HSD17B10
Gene Alias
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Gene Description
hydroxysteroid (17-beta) dehydrogenase 10
Gene Ontology
HyperlinkGene Summary
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq
Other Designations
17-beta-hydroxysteroid dehydrogenase type 10|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|AB-binding alcohol dehydrogenase|OTTHUMP00000023348|OTTHUMP00000023349|amyloid-beta binding polypeptide|amyloid-beta peptide binding alcohol dehydrogenase|mental reta
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Interactome
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Pathway
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Publication Reference
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A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease.
He XY, Schulz H, Yang SY.
The Journal of Biological Chemistry 1998 Apr; 273(17):10741.
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A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease.
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