PSMD2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PSMD2.
Immunogen
A synthetic peptide corresponding to human PSMD2.
Sequence
C-VILRKNPNYDL
Host
Goat
Theoretical MW (kDa)
100
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.03-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
PSMD2 polyclonal antibody (Cat # PAB6715) (0.03 ug/mL) staining of A-431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PSMD2
Entrez GeneID
5708Protein Accession#
NP_002799Gene Name
PSMD2
Gene Alias
MGC14274, P97, Rpn1, S2, TRAP2
Gene Description
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Omim ID
606223Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq
Other Designations
26S proteasome non-ATPase regulatory subunit 2|26S proteasome regulatory subunit S2|26S proteasome subunit p97|55.11 protein|TNFR-associated protein 2|proteasome 26S non-ATPase subunit 2|tumor necrosis factor receptor-associated protein 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family.
Fanindra Kumar Deshmukh, Gili Ben-Nissan, Maya A Olshina, Maria G Füzesi-Levi, Caley Polkinghorn, Galina Arkind, Yegor Leushkin, Irit Fainer, Sarel J Fleishman, Dan Tawfik, Michal Sharon.
Nature Communications 2023 May; 14(1):3126.
Application:WB, Human, Human breast cancer T47D cells.
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Allosteric regulation of the 20S proteasome by the Catalytic Core Regulators (CCRs) family.
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