HPGD polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
HPGD polyclonal antibody (Cat # PAB6712) (0.1 ug/mL) staining of human duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
HPGD polyclonal antibody (Cat # PAB6712) (2.5 ug/mL) staining of paraffin embedded human colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HPGD.
Immunogen
A synthetic peptide corresponding to human HPGD.
Sequence
C-DYDTTPFQAKTQ
Host
Goat
Theoretical MW (kDa)
29
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western blot (0.1-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HPGD polyclonal antibody (Cat # PAB6712) (0.1 ug/mL) staining of human duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
HPGD polyclonal antibody (Cat # PAB6712) (2.5 ug/mL) staining of paraffin embedded human colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HPGD
Entrez GeneID
3248Protein Accession#
NP_000851Gene Name
HPGD
Gene Alias
15-PGDH, PGDH, PGDH1, SDR36C1
Gene Description
hydroxyprostaglandin dehydrogenase 15-(NAD)
Omim ID
601688Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
15-hydroxy prostaglandin dehydrogenase|15-hydroxyprostaglandin dehydrogenase|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase|short chain dehydrogenase/reductase family 36C, member 1
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Interactome
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Disease
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Publication Reference
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Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.
Coggins KG, Latour A, Nguyen MS, Audoly L, Coffman TM, Koller BH.
Nature Medicine 2002 Feb; 8(2):91.
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Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.
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