CREM polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
CREM polyclonal antibody (Cat # PAB6696) staining (1 ug/mL) of human heart lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
-
Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CREM.
Immunogen
A synthetic peptide corresponding to human CREM.
Sequence
LETLKDICSPKTDY
Host
Goat
Theoretical MW (kDa)
32.5, 12.2, 13.5, 12
Reactivity
Human
Specificity
This antibody is expected to recognize the following protein isoforms of human CREM protein: a (NP_853549.1), e (NP_874387.1), f (NP_874388.1), k (NP_874393.1), l (NP_874394.1), m (NP_877570.1), n (NP_877571.1), o (NP_877572.1), p (NP_877573.1), q (NP_878270.1), v (NP_898883.1). This antibody is not expected to cross-react with CREB protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
CREM polyclonal antibody (Cat # PAB6696) staining (1 ug/mL) of human heart lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — CREM
Entrez GeneID
1390Protein Accession#
NP_853549.1;NP_874387.1;NP_874388.1;NP_874393.1;NP_874394.1;NP_877570.1;NP_877571.1;NP_877572.1;NP_877573.1;NP_878270.1;NP_898883.1Gene Name
CREM
Gene Alias
ICER, MGC111110, MGC17881, MGC41893, hCREM-2
Gene Description
cAMP responsive element modulator
Omim ID
123812Gene Ontology
HyperlinkGene Summary
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq
Other Designations
OTTHUMP00000019442|OTTHUMP00000019443|OTTHUMP00000019444|OTTHUMP00000019446|OTTHUMP00000019448|cAMP response element modulator|hCREM 2alpha-b protein|hCREM 2beta-a protein|inducible cAMP early repressor ICER
-
Interactome
-
Disease
-
Publication Reference
-
The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism.
Tenbrock K, Juang YT, Tolnay M, Tsokos GC.
The Journal of Immunology 2003 Mar; 170(6):2971.
Application：WB-Ce, ChIP, Human, T cells.
-
The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com