RXRG polyclonal antibody
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Specifications
Product Description
Goat polyclonal antibody raised against synthetic peptide of RXRG.
Immunogen
A synthetic peptide corresponding to human RXRG.
Sequence
RQRSRERAESEAEC
Host
Goat
Theoretical MW (kDa)
50.9
Reactivity
Human
Specificity
This antibody is expected to recognize human RXR gamma protein (hinge region) and does not cross-react with either RXR alpha or beta.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.3-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
RXRG polyclonal antibody (Cat # PAB6694) (0.3 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RXRG
Entrez GeneID
6258Protein Accession#
NP_008848Gene Name
RXRG
Gene Alias
NR2B3, RXRC
Gene Description
retinoid X receptor, gamma
Omim ID
180247Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000060418|retinoic acid receptor RXR-gamma|retinoid X receptor-gamma
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.
Samad TA, Krezel W, Chambon P, Borrelli E.
PNAS 1997 Dec; 94(26):14349.
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Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.
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