RXRB polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RXRB.
Immunogen
A synthetic peptide corresponding to human RXRB.
Sequence
CRDGMGDSGRDSRSP
Host
Goat
Theoretical MW (kDa)
56.9
Reactivity
Human
Specificity
This antibody is expected to recognize human RXR beta protein and does not cross-react with either RXR alpha or gamma.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
RXRB polyclonal antibody (Cat # PAB6693) staining (1 ug/mL) of A-431 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Western Blot (Transfected lysate)
HEK293 overexpressing RXRB and probed with RXRB polyclonal antibody (Cat # PAB6693) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RXRB
Entrez GeneID
6257Protein Accession#
NP_068811Gene Name
RXRB
Gene Alias
DAUDI6, H-2RIIBP, MGC1831, NR2B2, RCoR-1
Gene Description
retinoid X receptor, beta
Omim ID
180246Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. [provided by RefSeq
Other Designations
MHC class I promoter binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.
Samad TA, Krezel W, Chambon P, Borrelli E.
PNAS 1997 Dec; 94(26):14349.
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Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family.
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