NR1H3/NR1H2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NR1H3/NR1H2.
Immunogen
A synthetic peptide corresponding to human NR1H3, NR1H2.
Sequence
CRLQDKKLPPLLSEI
Host
Goat
Theoretical MW (kDa)
50.5, 50.1
Reactivity
Human, Mouse, Rat
Specificity
This antibody is expected to recognize an epitope corresponding to aa 429-442 of human LXR alpha protein (NP_005684) and to aa 443-456 of human LXR beta protein (NP_009052).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The NR1H3/NR1H2 polyclonal antibody (Cat # PAB6691) (1 ug/mL) staining of human spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NR1H2
Entrez GeneID
7376Protein Accession#
NP_005684 (Gene ID : 10062);NP_009052 (Gene ID : 7376)Gene Name
NR1H2
Gene Alias
LXR-b, LXRB, NER, NER-I, RIP15, UNR
Gene Description
nuclear receptor subfamily 1, group H, member 2
Omim ID
600380Gene Ontology
HyperlinkGene Summary
The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM
Other Designations
LX receptor beta|liver X receptor beta|liver X receptor-beta|nuclear orphan receptor LXR-beta|oxysterols receptor LXR-beta|steroid hormone-nuclear receptor NER|ubiquitously-expressed nuclear receptor
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Gene Info — NR1H3
Entrez GeneID
10062Protein Accession#
NP_005684 (Gene ID : 10062);NP_009052 (Gene ID : 7376)Gene Name
NR1H3
Gene Alias
LXR-a, LXRA, RLD-1
Gene Description
nuclear receptor subfamily 1, group H, member 3
Omim ID
602423Gene Ontology
HyperlinkGene Summary
group H
Other Designations
liver X receptor alpha|liver X receptor, alpha|liver X receptor-alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.
PNAS 2002 Sep; 99(18):11896.
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Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
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