DLC1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DLC1 polyclonal antibody (Cat # PAB6661) (5 ug/mL) staining of paraffin embedded human adrenal gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DLC1.
Immunogen
A synthetic peptide corresponding to N-terminus of human DLC1.
Sequence
SVAIRKRSWEEHC
Host
Goat
Reactivity
Human
Specificity
This antibody is expected to recognize isoforms 1 and 3 ( NP_872584.1 and NP_079043.2 resp) but NOT isoform 2 (NP_006085.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DLC1 polyclonal antibody (Cat # PAB6661) (5 ug/mL) staining of paraffin embedded human adrenal gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DLC1
Entrez GeneID
10395Protein Accession#
NP_872584.2;NP_079043.3Gene Name
DLC1
Gene Alias
ARHGAP7, FLJ21120, HP, STARD12, p122-RhoGAP
Gene Description
deleted in liver cancer 1
Omim ID
604258Gene Ontology
HyperlinkGene Summary
This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers. Alternative splicing at this locus results in several transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000116050|Rho-GTPase-activating protein 7|START domain containing protein 12|StAR-related lipid transfer (START) domain containing 12|StAR-related lipid transfer protein 12|deleted in liver cancer 1 variant 2
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Interactome
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Disease
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Publication Reference
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Sequence variants of DLC1 in colorectal and ovarian tumours.
Wilson PJ, McGlinn E, Marsh A, Evans T, Arnold J, Wright K, Biden K, Young J, Wainwright B, Wicking C, Chenevix-Trench G.
Human Mutation 2000 Jan; 15(2):156.
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Sequence variants of DLC1 in colorectal and ovarian tumours.
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