HPS3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HPS3.
Immunogen
A synthetic peptide corresponding to human HPS3.
Sequence
PYLLYCSRKKPLT
Host
Goat
Theoretical MW (kDa)
114
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
HPS3 polyclonal antibody (Cat # PAB6657) (1 ug/mL) staining of A-431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HPS3
Entrez GeneID
84343Protein Accession#
NP_115759Gene Name
HPS3
Gene Alias
DKFZp686F0413, FLJ22704, SUTAL
Gene Description
Hermansky-Pudlak syndrome 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing a potential clathrin-binding motif, consensus dileucine signals, and tyrosine-based sorting signals for targeting to vesicles of lysosomal lineage. The encoded protein may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 3. Alternate splice variants exist, but their full length sequence has not been determined. [provided by RefSeq
Other Designations
Hermansky-Pudlak syndrome 3 protein
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Interactome
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Disease
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Publication Reference
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The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2).
Gautam R, Chintala S, Li W, Zhang Q, Tan J, Novak EK, Di Pietro SM, Dell'Angelica EC, Swank RT.
The Journal of Biological Chemistry 2004 Mar; 279(13):12935.
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The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2).
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