MCL1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
MCL1 polyclonal antibody (Cat # PAB6639) staining (1 ug/mL) of human lung lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MCL1.
Immunogen
A synthetic peptide corresponding to human MCL1.
Sequence
C-AGVGAGLAYLIR
Host
Goat
Theoretical MW (kDa)
37.3
Reactivity
Human, Mouse, Rat
Specificity
This antibody is expected to recognize isoform 1 (NP_068779.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MCL1 polyclonal antibody (Cat # PAB6639) staining (1 ug/mL) of human lung lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MCL1
Entrez GeneID
4170Protein Accession#
NP_068779.1Gene Name
MCL1
Gene Alias
BCL2L3, EAT, MCL1L, MCL1S, MGC104264, MGC1839, TM
Gene Description
myeloid cell leukemia sequence 1 (BCL2-related)
Omim ID
159552Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq
Other Designations
OTTHUMP00000032794|OTTHUMP00000032795|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia sequence 1|myeloid cell leukemia sequence 1, isoform 1
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Interactome
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Disease
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Publication Reference
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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
Joseph T Opferman, Anthony Letai, Caroline Beard, Mia D Sorcinelli, Christy C Ong, Stanley J Korsmeyer.
Nature 2003 Dec; 426(6967):671.
Application：WB-Ce, WB-Tr, Mouse, MEFs, Mouse T cells, Mouse thymocytes.
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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
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