RGS14 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
RGS14 polyclonal antibody (Cat # PAB6630) staining (0.5 ug/mL) of Jurkat lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RGS14.
Immunogen
A synthetic peptide corresponding to human RGS14.
Sequence
C-IGGSLNSTTDSAL
Host
Goat
Theoretical MW (kDa)
61.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
RGS14 polyclonal antibody (Cat # PAB6630) staining (0.5 ug/mL) of Jurkat lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RGS14
Entrez GeneID
10636Protein Accession#
NP_006471Gene Name
RGS14
Gene Alias
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Gene Description
regulator of G-protein signaling 14
Omim ID
602513Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
regulator of G-protein signalling 14
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Interactome
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Disease
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Publication Reference
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Molecular cloning and expression analysis of rat Rgs12 and Rgs14.
Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP.
Biochemical and Biophysical Research Communications 1997 Apr; 233(3):770.
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Molecular cloning and expression analysis of rat Rgs12 and Rgs14.
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