CDC42BPA polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CDC42BPA polyclonal antibody (Cat # PAB6628)(3.8 ug/mL) staining of paraffin embedded human cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CDC42BPA.
Immunogen
A synthetic peptide corresponding to N-terminus of human CDC42BPA.
Sequence
SGEVRLRQLEQFI-C
Host
Goat
Theoretical MW (kDa)
186, 196
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CDC42BPA polyclonal antibody (Cat # PAB6628)(3.8 ug/mL) staining of paraffin embedded human cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDC42BPA
Entrez GeneID
8476Protein Accession#
NP_055641.3;NP_003598.2Gene Name
CDC42BPA
Gene Alias
DKFZp686L1738, DKFZp686P1738, FLJ23347, KIAA0451, MRCK, MRCKA, PK428
Gene Description
CDC42 binding protein kinase alpha (DMPK-like)
Omim ID
603412Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq
Other Designations
CDC42 binidng protein kinase beta|CDC42-binding protein kinase alpha|CDC42-binding protein kinase alpha (DMPK-like)|OTTHUMP00000035727|OTTHUMP00000035728|myotonic dystrophy kinase-related CDC42-binding protein kinase alpha|ser-thr protein kinase PK428|ser
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Interactome
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Disease
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Publication Reference
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Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.
Zhao Y, Loyer P, Li H, Valentine V, Kidd V, Kraft AS.
The Journal of Biological Chemistry 1997 Apr; 272(15):10013.
Application：IP, KA, WB-Ce, WB-Tr, Human, Monkey, COS-7, MDA-MB-231 cells.
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Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.
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