PAX3 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PAX3 polyclonal antibody (Cat # PAB6614) (3 ug/mL) staining of paraffin embedded human esophagus. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PAX3.
Immunogen
A synthetic peptide corresponding to human PAX3.
Sequence
TTLAGAVPRMM-C
Host
Goat
Theoretical MW (kDa)
24.1, 22.7, 53, 53.5
Reactivity
Human
Specificity
This antibody is expected to recognize all 7 reported human isoforms (as represented by NP_000429.2, NP_0.39230.1, NP_852122,.1 NP_852123.1, NP_852124.1, NP_852125.1 and NP_852126.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Immunohistochemistry (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PAX3 polyclonal antibody (Cat # PAB6614) (3 ug/mL) staining of paraffin embedded human esophagus. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PAX3
Entrez GeneID
5077Protein Accession#
NP_000429.2;NP_0.39230.1;NP_852122;.1NP_852123.1;NP_852124.1;NP_852125.1;NP_852126.1Gene Name
PAX3
Gene Alias
CDHS, HUP2, MGC120381, MGC120382, MGC120383, MGC120384, MGC134778, WS1
Gene Description
paired box 3
Gene Ontology
HyperlinkGene Summary
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq
Other Designations
paired box homeotic gene 3|paired domain gene 3|paired domain gene HuP2
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Interactome
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Disease
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Publication Reference
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Isolation of two isoforms of the PAX3 gene transcripts and their tissue-specific alternative expression in human adult tissues.
Tsukamoto K, Nakamura Y, Niikawa N.
Human Genetics 1994 Mar; 93(3):270.
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Isolation of two isoforms of the PAX3 gene transcripts and their tissue-specific alternative expression in human adult tissues.
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