DISP1 polyclonal antibody
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More Files
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Immunofluorescence
DISP1 polyclonal antibody (Cat # PAB6595) (2.5 ug/mL) staining of U87 MG. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DISP1.
Immunogen
A synthetic peptide corresponding to human DISP1.
Sequence
C-SELSGESLLIKTL
Host
Goat
Theoretical MW (kDa)
171
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
DISP1 polyclonal antibody (Cat # PAB6595) (2.5 ug/mL) staining of U87 MG. Detected by immunofluorescence. Data provided by Dr. Aashir Awan, University of Madrid, Spain.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DISP1
Entrez GeneID
84976Protein Accession#
NP_116279Gene Name
DISP1
Gene Alias
DISPA, DKFZp434I0428, FLJ43740, MGC104180, MGC13130, MGC16796
Gene Description
dispatched homolog 1 (Drosophila)
Omim ID
607502Gene Ontology
HyperlinkGene Summary
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq
Other Designations
OTTHUMP00000036011|dispatched A
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Interactome
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Disease
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Publication Reference
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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.
Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, Dickson BJ, Basler K.
Cell 1999 Dec; 99(7):803.
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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.
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