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Last updated: 2016/12/4
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RANGAP1 polyclonal antibody

  • Catalog # : PAB6571
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of RANGAP1.
  • Immunogen:
  • A synthetic peptide corresponding to human RANGAP1.
  • Sequence:
  • ASEDIAKLAETLAK-C
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 63.5
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • In mouse, there is a hypothetical protein called "similar to RANGAP1" (XP_139737.2) that is virtually identical.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:32000)
    Western blot (0.1-0.5 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • RANGAP1 polyclonal antibody (Cat # PAB6571) staining (0.2 ug/mL) of NIH/3T3 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • RANGAP1 polyclonal antibody (Cat # PAB6571) (2.5 ug/mL) staining of paraffin embedded human liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5905
  • Gene Name:
  • RANGAP1
  • Gene Alias:
  • Fug1,KIAA1835,MGC20266,SD
  • Gene Description:
  • Ran GTPase activating protein 1
  • Gene Summary:
  • RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000028918,segregation distorter homolog,segregation distortion
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