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Last updated: 2016/11/27
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KPNA2 polyclonal antibody

  • Catalog # : PAB6558
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of KPNA2.
  • Immunogen:
  • A synthetic peptide corresponding to human KPNA2.
  • Sequence:
  • C-QVQDGAPGTFNF
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 57.9
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:32000)
    Western Blot (0.1-0.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • KPNA2 polyclonal antibody (Cat # PAB6558) staining (0.1 ug/mL) of HeLa lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • Immunofluorescence
  • Immunofluorescence
  • KPNA2 polyclonal antibody (Cat # PAB6558) staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red) . Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 3838
  • Gene Name:
  • KPNA2
  • Gene Alias:
  • IPOA1,QIP2,RCH1,SRP1alpha
  • Gene Description:
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
  • Gene Summary:
  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq
  • Other Designations:
  • RAG cohort 1,importin alpha 1,importin alpha 2,importin-alpha-P1,karyopherin alpha 2,pendulin
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