KALRN polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
KALRN polyclonal antibody (Cat # PAB6507) (0.5 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of KALRN.
Immunogen
A synthetic peptide corresponding to C-terminus of human KALRN.
Sequence
C-RWHLGPGDPFSTYV
Host
Goat
Theoretical MW (kDa)
192
Reactivity
Human, Mouse
Specificity
This antibody is expected to recognize isoform 2 (NP_0.03938.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
KALRN polyclonal antibody (Cat # PAB6507) (0.5 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — KALRN
Entrez GeneID
8997Protein Accession#
NP_0.03938.1Gene Name
KALRN
Gene Alias
DUET, FLJ16443, HAPIP, TRAD, duo
Gene Description
kalirin, RhoGEF kinase
Omim ID
604605Gene Ontology
HyperlinkGene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000165775|huntingtin-associated protein interacting protein (duo)|serine/threonine kinase with Dbl- and pleckstrin homology domains
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Interactome
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Disease
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Publication Reference
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Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
Colomer V, Engelender S, Sharp AH, Duan K, Cooper JK, Lanahan A, Lyford G, Worley P, Ross CA.
Human Molecular Genetics 1997 Sep; 6(9):1519.
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Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
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