ARHGEF4 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
ARHGEF4 polyclonal antibody (Cat # PAB6484) staining (2 ug/mL) of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ARHGEF4.
Immunogen
A synthetic peptide corresponding to human ARHGEF4.
Sequence
PWEEPAGEKPSCS
Host
Goat
Theoretical MW (kDa)
79.1, 76.4
Reactivity
Human
Specificity
This antibody is expected to recognize both human isoforms of this protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ARHGEF4 polyclonal antibody (Cat # PAB6484) staining (2 ug/mL) of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ARHGEF4
Entrez GeneID
50649Protein Accession#
NP_056135;NP_127462Gene Name
ARHGEF4
Gene Alias
ASEF, ASEF1, GEF4, STM6
Gene Description
Rho guanine nucleotide exchange factor (GEF) 4
Omim ID
605216Gene Ontology
HyperlinkGene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene. [provided by RefSeq
Other Designations
APC-stimulated guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor 4
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Interactome
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Pathway
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Publication Reference
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Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22.
Thiesen S, Kubart S, Ropers HH, Nothwang HG.
Biochemical and Biophysical Research Communications 2000 Jun; 273(1):364.
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Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22.
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