FOXN1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FOXN1.
Immunogen
A synthetic peptide corresponding to human FOXN1.
Sequence
C-SVYLSPSSKPVALA
Host
Goat
Theoretical MW (kDa)
68.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (20-30 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
FOXN1 polyclonal antibody (Cat # PAB6466) staining (20 ug/mL) of paraffin embedded human thymus medulla. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FOXN1
Entrez GeneID
8456Protein Accession#
NP_0.03584Gene Name
FOXN1
Gene Alias
FKHL20, RONU, WHN
Gene Description
forkhead box N1
Omim ID
600838Gene Ontology
HyperlinkGene Summary
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq
Other Designations
Rowett nude|winged helix nude|winged-helix nude
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Interactome
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Disease
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Publication Reference
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Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype.
Schlake T, Schorpp M, Maul-Pavicic A, Malashenko AM, Boehm T.
Developmental Dynamics 2000 Apr; 217(4):368.
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Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype.
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