MAPK8IP3 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MAPK8IP3.
Immunogen
A synthetic peptide corresponding to N-terminus of human MAPK8IP3.
Sequence
MEIQMDEGGGVV-C
Host
Goat
Theoretical MW (kDa)
148, 147
Reactivity
Mouse
Specificity
This antibody is expected to recognize both reported human isoforms of this protein (as represented by NP_055948.1 and NP_20.3750.3).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:4000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
MAPK8IP3 polyclonal antibody (Cat # PAB6403) (4 ug/mL) staining of paraffin embedded mouse brain. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAPK8IP3
Entrez GeneID
23162Protein Accession#
NP_055948.1;NP_20.3750.3Gene Name
MAPK8IP3
Gene Alias
DKFZp762N1113, FLJ00027, JIP3, JSAP1, KIAA1066, SYD2
Gene Description
mitogen-activated protein kinase 8 interacting protein 3
Omim ID
605431Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq
Other Designations
C-jun-amino-terminal kinase interacting protein 3|JNK-interacting protein 3|JNK/SAPK-associated protein-1|JNK/stress-activated protein kinase-associated protein 1|OTTHUMP00000158803|homolog of Drosophila Sunday driver 2
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Interactome
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Pathway
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Publication Reference
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Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.
Kelkar N, Gupta S, Dickens M, Davis RJ.
Molecular and Cellular Biology 2000 Feb; 20(3):1030.
Application:IF, WB-Ti, WB-Tr, Mouse, Monkey, Rat, COS-7 cells, Mouse tissues, PC-12 cells.
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Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.
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