EDD1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
EDD1 polyclonal antibody (4 ug/mL) staining of paraffin embedded human testis. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not be obtained after antigen retrieval at pH6.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of EDD1.
Immunogen
A synthetic peptide corresponding to C-terminus of human EDD1.
Sequence
C-LAIKTKNFGFV
Host
Goat
Reactivity
Human, Mouse, Rabbit, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:4000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
EDD1 polyclonal antibody (4 ug/mL) staining of paraffin embedded human testis. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not be obtained after antigen retrieval at pH6.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — UBR5
Entrez GeneID
51366Protein Accession#
NP_056986.2Gene Name
UBR5
Gene Alias
DD5, EDD, EDD1, FLJ11310, HYD, KIAA0896, MGC57263
Gene Description
ubiquitin protein ligase E3 component n-recognin 5
Omim ID
608413Gene Ontology
HyperlinkGene Summary
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq
Other Designations
E3 identified by differential display|E3 ubiquitin protein ligase, HECT domain containing, 1|hyperplastic discs protein homolog|progestin induced protein|ubiquitin-protein ligase
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Interactome
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Pathway
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Publication Reference
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EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.
Henderson MJ, Russell AJ, Hird S, Munoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK.
The Journal of Biological Chemistry 2002 Jul; 277(29):26468.
Application：ICC, IF, Human, HEK 293, MCF-7, T-47D cells.
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EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.
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