NEIL1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NEIL1 polyclonal antibody (Cat # PAB6342, 5 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NEIL1.
Immunogen
A synthetic peptide corresponding to human NEIL1.
Sequence
C-DIPSLEPEGTSAS
Host
Goat
Theoretical MW (kDa)
43.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NEIL1 polyclonal antibody (Cat # PAB6342, 5 ug/mL) staining of paraffin embedded human placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NEIL1
Entrez GeneID
79661Protein Accession#
NP_078884.1Gene Name
NEIL1
Gene Alias
FLJ22402, FPG1, NEI1, hFPG1
Gene Description
nei endonuclease VIII-like 1 (E. coli)
Omim ID
608844Gene Ontology
HyperlinkGene Summary
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM
Other Designations
endonuclease VIII|nei endonuclease VIII-like 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.
Hazra TK, Izumi T, Boldogh I, Imhoff B, Kow YW, Jaruga P, Dizdaroglu M, Mitra S.
PNAS 2002 Mar; 99(6):3523.
Application：WB-Ce, Human, MRC5 cells.
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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.
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