SIGLEC12 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SIGLEC12.
Immunogen
A synthetic peptide corresponding to human SIGLEC12.
Sequence
C-EAIGYEYSEINIPK
Host
Goat
Theoretical MW (kDa)
51.7, 65
Specificity
This antibody is expected to recognize both human isoforms of this protein (NP_201586; NP_443729).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SIGLEC12
Entrez GeneID
89858Protein Accession#
NP_201586;NP_443729Gene Name
SIGLEC12
Gene Alias
FLJ38600, S2V, SIGLECL1, SLG, Siglec-12, Siglec-L1, Siglec-XII
Gene Description
sialic acid binding Ig-like lectin 12
Omim ID
606094Gene Ontology
HyperlinkGene Summary
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
Other Designations
SIGLEC-like 1|sialic acid binding immunoglobulin-like lectin-like protein 1
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Interactome
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Disease
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Publication Reference
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Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs.
Yu Z, Lai CM, Maoui M, Banville D, Shen SH.
The Journal of Biological Chemistry 2001 Jun; 276(26):23816.
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Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs.
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