TRIM24 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TRIM24 polyclonal antibody (Cat # PAB6318) (4 ug/mL) staining of paraffin embedded human breast cancer. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TRIM24.
Immunogen
A synthetic peptide corresponding to C-terminus of human TRIM24.
Sequence
C-KRLKSIEERQLLK
Host
Goat
Theoretical MW (kDa)
117, 113
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms, as represented by NP_003843.3 and NP_056989.2.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TRIM24 polyclonal antibody (Cat # PAB6318) (4 ug/mL) staining of paraffin embedded human breast cancer. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TRIM24
Entrez GeneID
8805Protein Accession#
NP_056989.2;NP_003843.3Gene Name
TRIM24
Gene Alias
PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Gene Description
tripartite motif-containing 24
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
transcriptional intermediary factor 1|transcriptional intermediary factor 1 alpha|tripartite motif protein 24
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Interactome
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Publication Reference
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Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.
Thenot S, Henriquet C, Rochefort H, Cavailles V.
The Journal of Biological Chemistry 1997 May; 272(18):12062.
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Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.
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