CCNDBP1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CCNDBP1.
Immunogen
A synthetic peptide corresponding to C-terminus of human CCNDBP1.
Sequence
C-NRIKELTQSELEL
Host
Goat
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CCNDBP1 polyclonal antibody (Cat # PAB6283)(3.8 ug/mL) staining of paraffin embedded human prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCNDBP1
Entrez GeneID
23582Protein Accession#
NP_036274.3;NP_411241.1Gene Name
CCNDBP1
Gene Alias
DIP1, GCIP
Gene Description
cyclin D-type binding-protein 1
Omim ID
607089Gene Ontology
HyperlinkGene Summary
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq
Other Designations
D-type cyclin-interacting protein 1|HHM Protein|MAID protein|grap2 cyclin interacting protein
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Interactome
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Publication Reference
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GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity.
Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M.
The Journal of Biological Chemistry 2000 Jul; 275(27):20942.
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GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity.
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