RNF19 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RNF19.
Immunogen
A synthetic peptide corresponding to human RNF19.
Sequence
C-QTMELKVAIQTEI
Host
Goat
Theoretical MW (kDa)
90.7
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — RNF19A
Entrez GeneID
25897Protein Accession#
NP_056250Gene Name
RNF19A
Gene Alias
DKFZp566B1346, DORFIN, RNF19
Gene Description
ring finger protein 19A
Omim ID
607119Gene Ontology
HyperlinkGene Summary
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq
Other Designations
RING finger protein 19 isoform|double ring-finger protein|p38 protein|protein p38 interacting with transcription factor Sp1|ring finger protein 19|ring-IBR-ring domain containing protein Dorfin
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Interactome
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Publication Reference
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A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.
Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G.
Biochemical and Biophysical Research Communications 2001 Mar; 281(3):706.
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A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.
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