RAD51C polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RAD51C.
Immunogen
A synthetic peptide corresponding to human RAD51C.
Sequence
RGKTFRFEMQRDL-C
Host
Goat
Theoretical MW (kDa)
14.9, 42.2
Reactivity
Human
Specificity
This antibody is expected to recognize all three human isoforms.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
RAD51C polyclonal antibody (Cat # PAB6271) staining (2 ug/mL) of HeLa lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RAD51C
Entrez GeneID
5889Protein Accession#
NP_002867;NP_478123;NP_478124Gene Name
RAD51C
Gene Alias
MGC104277, RAD51L2
Gene Description
RAD51 homolog C (S. cerevisiae)
Omim ID
602774Gene Ontology
HyperlinkGene Summary
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
DNA repair protein RAD51 homolog 3|RAD51 homolog C|RAD51 homolog C, isoform 1|yeast RAD51 homolog 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.
Dosanjh MK, Collins DW, Fan W, Lennon GG, Albala JS, Shen Z, Schild D.
Nucleic Acids Research 1998 Mar; 26(5):1179.
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Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.
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