CENPF polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CENPF.
Immunogen
A synthetic peptide corresponding to C-terminus of human CENPF.
Sequence
GLESKGSENCKVQ
Host
Goat
Theoretical MW (kDa)
358
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CENPF
Entrez GeneID
1063Protein Accession#
AAA82889.1;AAA82935.1;AAA86889.1Gene Name
CENPF
Gene Alias
CENF, PRO1779, hcp-1
Gene Description
centromere protein F, 350/400ka (mitosin)
Omim ID
600236Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq
Other Designations
AH antigen|CENP-F kinetochore protein|OTTHUMP00000035028|cell-cycle-dependent 350K nuclear protein|centromere protein F|mitosin
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Interactome
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Disease
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Publication Reference
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CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.
Liao H, Winkfein RJ, Mack G, Rattner JB, Yen TJ.
The Journal of Cell Biology 1995 Aug; 130(3):507.
Application：IF, IP, WB-Ce, Human, HeLa cells.
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CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.
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