Products

Western Blot (Cell lysate)

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

Protein Accession#

Gene Name

TBPL1

Gene Alias

MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2

Gene Description

TBP-like 1

Omim ID

Gene Ontology

Gene Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes. [provided by RefSeq

Other Designations

21-kDA TBP-like protein|OTTHUMP00000017240|TATA box binding protein-related factor 2|TBP-like protein|TBP-related factor 2|second TBP of unique DNA