IRF8 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
IRF8 polyclonal antibody (Cat # PAB6228) staining (1 ug/mL) of K-562 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IRF8.
Immunogen
A synthetic peptide corresponding to human IRF8.
Sequence
C-QRSFFRENQQITV
Host
Goat
Theoretical MW (kDa)
48.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
IRF8 polyclonal antibody (Cat # PAB6228) staining (1 ug/mL) of K-562 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRF8
Entrez GeneID
3394Protein Accession#
NP_002154Gene Name
IRF8
Gene Alias
H-ICSBP, ICSBP, ICSBP1, IRF-8
Gene Description
interferon regulatory factor 8
Omim ID
601565Gene Ontology
HyperlinkGene Summary
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq
Other Designations
interferon consensus sequence binding protein 1
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Interactome
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Disease
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Publication Reference
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Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ.
The Journal of Biological Chemistry 1992 Dec; 267(35):25589.
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Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
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