NOS1AP polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NOS1AP.
Immunogen
A synthetic peptide corresponding to human NOS1AP.
Sequence
PSKTKYNLVDDGH-C
Host
Goat
Theoretical MW (kDa)
56.1, 55.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NOS1AP polyclonal antibody (Cat # PAB6226) staining (5 ug/mL) of paraffin embedded human liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NOS1AP
Entrez GeneID
9722Protein Accession#
NP_055512.1Gene Name
NOS1AP
Gene Alias
6330408P19Rik, CAPON, MGC138500
Gene Description
nitric oxide synthase 1 (neuronal) adaptor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)|OTTHUMP00000025714|ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain
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Interactome
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Disease
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Publication Reference
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CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.
Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH.
Neuron 1998 Jan; 20(1):115.
Application:IHC-Fr, WB-Re, WB-Ti, WB-Tr, Human, Mouse, Rat, HEK 293 cells, Mouse cerebellar lysates, Recombinant protein, Rat brains.
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CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.
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