IRF2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
IRF2 polyclonal antibody (Cat # PAB6225) staining (2 ug/mL) of Jurkat lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Western Blot (Transfected lysate)
HEK293 overexpressing IRF2 and probed with IRF2 polyclonal antibody (Cat # PAB6225) (mock transfection in first lane), tested by Origene.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IRF2.
Immunogen
A synthetic peptide corresponding to C-terminus of human IRF2.
Sequence
KTSDITQARVKSC
Host
Goat
Theoretical MW (kDa)
39.3
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:2000)
Western blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
IRF2 polyclonal antibody (Cat # PAB6225) staining (2 ug/mL) of Jurkat lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Western Blot (Transfected lysate)
HEK293 overexpressing IRF2 and probed with IRF2 polyclonal antibody (Cat # PAB6225) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRF2
Entrez GeneID
3660Protein Accession#
NP_002190.2Gene Name
IRF2
Gene Alias
DKFZp686F0244, IRF-2
Gene Description
interferon regulatory factor 2
Omim ID
147576Gene Ontology
HyperlinkGene Summary
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.
Liljeroos M, Vuolteenaho R, Rounioja S, Henriques-Normark B, Hallman M, Ojaniemi M.
Cellular Signalling 2008 Jul; 20(10):1873.
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Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.
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