IPO8 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
IPO8 polyclonal antibody (Cat # PAB6210) (4 ug/mL) staining of paraffin embedded human tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Similar results were obtained after antigen retrieval at pH9.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IPO8.
Immunogen
A synthetic peptide corresponding to C-terminus of human IPO8.
Sequence
C-SAFNFGTVPSNN
Host
Goat
Reactivity
Human
Specificity
This antibody is expected to recognise isoform 1 (NP_006381.2) and isoform 2 (NP_001177924.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
IPO8 polyclonal antibody (Cat # PAB6210) (4 ug/mL) staining of paraffin embedded human tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Similar results were obtained after antigen retrieval at pH9.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IPO8
Entrez GeneID
10526Protein Accession#
NP_001177924.1Gene Name
IPO8
Gene Alias
FLJ26580, RANBP8
Gene Description
importin 8
Omim ID
605600Gene Ontology
HyperlinkGene Summary
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. [provided by RefSeq
Other Designations
RAN binding protein 8
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Interactome
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Publication Reference
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A novel class of RanGTP binding proteins.
Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E.
The Journal of Cell Biology 1997 Jul; 138(1):65.
Application：WB-Ce, Human, Frog, HeLa cells, Xenopus egg extracts.
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A novel class of RanGTP binding proteins.
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