PAX8 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PAX8.
Immunogen
A synthetic peptide corresponding to human PAX8.
Sequence
PHNSIRSGHGGLN-C
Host
Goat
Theoretical MW (kDa)
48.2, 41.7, 43, 34.9
Reactivity
Human
Specificity
This antibody is expected to recognize all five human isoforms (as represented by NP_0.03457.1, NP_0.39245.1, NP_0.39246.1, NP_0.39247.1, NP_054698.1)
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PAX8 polyclonal antibody (Cat # PAB6201) staining (3 ug/mL) of paraffin embedded human thyroid gland. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PAX8
Entrez GeneID
7849Protein Accession#
NP_0.03457.1;NP_0.39245.1;NP_0.39246.1;NP_0.39247.1;NP_054698.1Gene Name
PAX8
Gene Alias
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Gene Description
paired box 8
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternateively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000158659|OTTHUMP00000158660|paired domain gene 8
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Interactome
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Pathway
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Disease
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Publication Reference
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Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.
Borgogni E, Sarchielli E, Sottili M, Santarlasci V, Cosmi L, Gelmini S, Lombardi A, Cantini G, Perigli G, Luconi M, Vannelli GB, Annunziato F, Adorini L, Serio M, Crescioli C.
Endocrinology 2008 Jul; 149(7):3626.
Application:IF, Human, Human thyrocytes.
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Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes.
Crescioli C, Cosmi L, Borgogni E, Santarlasci V, Gelmini S, Sottili M, Sarchielli E, Mazzinghi B, Francalanci M, Pezzatini A, Perigli G, Vannelli GB, Annunziato F, Serio M.
The Journal of Endocrinology 2007 Oct; 195(1):145.
Application:Flow Cyt, Human, Human thyrocytes.
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Pax8 has a key role in thyroid cell differentiation.
M Pasca di Magliano, R Di Lauro, M Zannini.
PNAS 2000 Nov; 97(24):13144.
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Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.
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