ELF5 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ELF5 polyclonal antibody (Cat # PAB6200)(4 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ELF5.
Immunogen
A synthetic peptide corresponding to C-terminus of human ELF5.
Sequence
C-GKNAHGWQEDKL
Host
Goat
Reactivity
Human
Specificity
This antibody is expected to recognize both reported human isoforms represented by NP_938195.1 and NP_001413.1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:128000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-8 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ELF5 polyclonal antibody (Cat # PAB6200)(4 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ELF5
Entrez GeneID
2001Protein Accession#
NP_938195.1;NP_001413.1Gene Name
ELF5
Gene Alias
ESE2
Gene Description
E74-like factor 5 (ets domain transcription factor)
Omim ID
605169Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
E74-like factor 5|epithelium-specific Ets transcription factor 2
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Interactome
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Disease
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Publication Reference
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Effect of the normal mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients.
Omata F, McNamara KM, Suzuki K, Abe E, Hirakawa H, Ishida T, Ohuchi N, Sasano H.
Breast Cancer 2018 Feb; [Epub].
Application：IHC, Human, Breast cancer tissue, Prostate tissue.
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Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.
Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C, Libermann TA.
The Journal of Biological Chemistry 1999 Oct; 274(41):29439.
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Effect of the normal mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients.
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