TXNRD1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TXNRD1.
Immunogen
A synthetic peptide corresponding to human TXNRD1.
Sequence
TKRSGASILQAGC
Host
Goat
Theoretical MW (kDa)
54.7, 54.7, 70.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TXNRD1 polyclonal antibody (Cat # PAB6199) staining (0.1 ug/mL) of human placenta lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TXNRD1
Entrez GeneID
7296Protein Accession#
NP_003321Gene Name
TXNRD1
Gene Alias
GRIM-12, MGC9145, TR, TR1, TRXR1, TXNR
Gene Description
thioredoxin reductase 1
Omim ID
601112Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq
Other Designations
KM-102-derived reductase-like factor|oxidoreductase|thioredoxin reductase GRIM-12
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Interactome
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Pathway
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Disease
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Publication Reference
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Cloning and sequencing of a human thioredoxin reductase.
Gasdaska PY, Gasdaska JR, Cochran S, Powis G.
FEBS Letters 1995 Oct; 373(1):5.
Application:WB-Re, WB-Ti, Human, Human placenta, Recombinant protein.
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Cloning and sequencing of a human thioredoxin reductase.
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