JUP polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
JUP polyclonal antibody (Cat # PAB6193) staining (0.2 ug/mL) of A-431 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of JUP.
Immunogen
A synthetic peptide corresponding to C-terminus of human JUP.
Sequence
C-GLRPPYPTADHMLA
Host
Goat
Theoretical MW (kDa)
86
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms, as represented by NP_002221.1 and NP_068831.1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.2-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
JUP polyclonal antibody (Cat # PAB6193) staining (0.2 ug/mL) of A-431 lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
Enzyme Immunoassay
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Gene Info — JUP
Entrez GeneID
3728Protein Accession#
NP_002221;NP_068831Gene Name
JUP
Gene Alias
ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Gene Description
junction plakoglobin
Gene Ontology
HyperlinkGene Summary
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq
Other Designations
OTTHUMP00000164735|catenin (cadherin-associated protein), gamma (80kD)|catenin (cadherin-associated protein), gamma 80kDa|gamma-catenin
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Interactome
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Pathway
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Disease
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Publication Reference
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Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.
Knudsen KA, Wheelock MJ.
The Journal of Cell Biology 1992 Aug; 118(3):671.
Application：IF, IP, WB-Ce, Chicken, Human, Chicken cardiac myocytes, Human epithelial cells.
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Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.
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