FXYD5 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FXYD5.
Immunogen
A synthetic peptide corresponding to human FXYD5.
Sequence
GKCRQLSRLCRNHCR
Host
Goat
Theoretical MW (kDa)
19.5
Reactivity
Human
Specificity
NP_054883.1 and NP_6590.03.1 are variants that represent the same protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
FXYD5 polyclonal antibody (Cat # PAB6132) staining (0.5 ug/mL) of human spleen lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FXYD5
Entrez GeneID
53827Protein Accession#
NP_054883.1;NP_6590.03.1Gene Name
FXYD5
Gene Alias
HSPC113, IWU-1, IWU1, KCT1, OIT2, PRO6241, RIC, dysad
Gene Description
FXYD domain containing ion transport regulator 5
Omim ID
606669Gene Ontology
HyperlinkGene Summary
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.
Other Designations
FXYD domain-containing ion transport regulator 5|dysadherin|keratinocytes associated transmembrane protein 1
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Interactome
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Disease
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Publication Reference
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Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S.
PNAS 2002 Jan; 99(1):365.
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Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
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