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Last updated: 2017/12/17
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FXYD5 polyclonal antibody

  • Catalog # : PAB6132
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of FXYD5.
  • Immunogen:
  • A synthetic peptide corresponding to human FXYD5.
  • Sequence:
  • GKCRQLSRLCRNHCR
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 19.5
  • Reactivity:
  • Human
  • Specificity:
  • NP_054883.1 and NP_6590.03.1 are variants that represent the same protein.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:8000)
    Western Blot (0.5-1.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • FXYD5 polyclonal antibody (Cat # PAB6132) staining (0.5 ug/mL) of human spleen lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Protein Accession#:
  • NP_054883.1;NP_6590.03.1
  • Gene Name:
  • FXYD5
  • Gene Alias:
  • HSPC113,IWU-1,IWU1,KCT1,OIT2,PRO6241,RIC,dysad
  • Gene Description:
  • FXYD domain containing ion transport regulator 5
  • Gene Summary:
  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.
  • Other Designations:
  • FXYD domain-containing ion transport regulator 5,dysadherin,keratinocytes associated transmembrane protein 1
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