DKK2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
DKK2 polyclonal antibody (Cat # PAB6128) staining (2 ug/mL) of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DKK2.
Immunogen
A synthetic peptide corresponding to human DKK2.
Sequence
ATYSSKARLHVCQKI
Host
Goat
Theoretical MW (kDa)
28.4
Reactivity
Human
Specificity
This antibody may crossreact with DKK4, unfortunately this has not yet been specifically tested.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DKK2 polyclonal antibody (Cat # PAB6128) staining (2 ug/mL) of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DKK2
Entrez GeneID
27123Protein Accession#
NP_055236Gene Name
DKK2
Gene Alias
DKK-2
Gene Description
dickkopf homolog 2 (Xenopus laevis)
Omim ID
605415Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq
Other Designations
dickkopf 2|dickkopf homolog 2|dickkopf related protein-2
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional and structural diversity of the human Dickkopf gene family.
Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA.
Gene 1999 Oct; 238(2):301.
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Functional and structural diversity of the human Dickkopf gene family.
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