SOCS4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SOCS4.
Immunogen
A synthetic peptide corresponding to C-terminus of human SOCS4.
Sequence
C-SKVRVLRIDAPEQQ
Host
Goat
Theoretical MW (kDa)
50.6
Reactivity
Human
Specificity
Both variants represent identical protein (NP_543143.1 and NP_955453.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SOCS4 polyclonal antibody (Cat # PAB6126) (3.8 ug/mL) staining of paraffin embedded human pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SOCS4
Entrez GeneID
122809Protein Accession#
NP_543143.1;NP_955453.1Gene Name
SOCS4
Gene Alias
DKFZp686J1568, SOCS7
Gene Description
suppressor of cytokine signaling 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
SH2 domain containing SOCS box protein|suppressor of cytokine signaling 7
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Interactome
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Pathway
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Disease
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Publication Reference
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Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
Kario E, Marmor MD, Adamsky K, Citri A, Amit I, Amariglio N, Rechavi G, Yarden Y.
The Journal of Biological Chemistry 2005 Feb; 280(8):7038.
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Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
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